Cotadutide
Metabolic / fat loss
Appetite, glucose, weight, and metabolic regulation
Reference-only summary of publicly discussed or source-listed patterns. Not medical advice and not a personal recommendation.
Mechanism & Use
- Compound type
- Incretin / metabolic peptide or small molecule
- Primary mechanism
- Incretin/amylin/glucagon-axis receptor modulation
- Primary market use
- Metabolic / fat loss
Pharmacology
- Molecular weight (Da)
- 3728.09
- Oral bioavailability
- Route-dependent / verify
- Half-life
- ~12 h–7 days depending analog/acylation
- Route tags
- SubQ; Injectable; route-dependent
- Evidence level
- MCE product listing / research chemical signal
- Clinical status
- Research chemical/reference listing
- Value-for-money score
- 8 / 10
Reported protocol signal
No clean popular protocol found in uploaded sources; create as research/reference entry and verify before public protocol display.
For orientation only. See disclaimer — always consult a licensed clinician before use.
Stackability
Commonly compared/stacked in metabolic and body-composition protocols; verify redundancy and risk.
Notes
Cotadutide (MEDI0382) acetate is a potent dual agonist of glucagon-like peptide-1 ( GLP-1 ) and GCGR with EC 50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide acetate exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide acetate can be used in the research of obesity and type 2 diabetes (T2D).