Ibutamoren / MK-677

GH Axis / Orexigenic

Increase GH/IGF-1 and appetite

Reading this compound Reference only

Information below is educational. Dosing, mechanisms and status fields are compiled from the source list at the bottom of this page — always verify against a licensed clinician before use.

Reference-only summary of publicly discussed or source-listed patterns. Not medical advice and not a personal recommendation.

Mechanism & Use

Compound type: Small molecule
Primary mechanism: Ghrelin receptor agonism
Primary market use: Hormone/body composition

Pharmacology

Molecular weight (Da): 528.7
Oral bioavailability: ~60%+
Half-life: ~4-6 h
Route tags: Route-dependent / verify
Evidence level: Clinical/research
Clinical status: Experimental
Value-for-money score: 6 / 10

Reported protocol signal

Treatment length: 4-6 weeks with at least 4-6 weeks off in-between Oral: • Males: 25 mg daily before bedtime on an empty stomach • Females: 12.5 mg daily before bedtime on an empty stomach (Peptide Therapy, Tailor Made Compounding Catalog, Metabolic Optimization Guide)

For orientation only. See disclaimer — always consult a licensed clinician before use.

Notes

Requires ongoing dosing

Sources

https://clinicaltrials.gov/