Matrixyl / Palmitoyl pentapeptide

Cosmetic / Skin

Wrinkle reduction and collagen-support positioning

Reading this compound Reference only

Information below is educational. Dosing, mechanisms and status fields are compiled from the source list at the bottom of this page — always verify against a licensed clinician before use.

Reference-only summary of publicly discussed or source-listed patterns. Not medical advice and not a personal recommendation.

Mechanism & Use

Compound type: Cosmetic peptide
Primary mechanism: Extracellular-matrix signaling
Primary market use: Aesthetics

Pharmacology

Molecular weight (Da): ~802
Oral bioavailability: N/A/topical
Half-life: ~5–60 min parent peptide; analogs may be longer
Route tags: SubQ; Injectable; route-dependent
Evidence level: Human/Cosmetic
Clinical status: Cosmetic
Value-for-money score: 7 / 10

Reported protocol signal

Topical: • Used in creams and serums with concentrations ranging from 2% to 8% (3% being optimal)

For orientation only. See disclaimer — always consult a licensed clinician before use.

Notes

Topical cosmetic peptide

Sources

https://pubmed.ncbi.nlm.nih.gov/