MOTS-c
Metabolic / Longevity
Metabolic flexibility and exercise-response positioning
Reference-only summary of publicly discussed or source-listed patterns. Not medical advice and not a personal recommendation.
Mechanism & Use
- Compound type
- Mitochondrial peptide
- Primary mechanism
- AMPK and mitochondrial-nuclear signaling
- Primary market use
- Metabolic/longevity
Pharmacology
- Molecular weight (Da)
- 2174.6
- Oral bioavailability
- N/A
- Half-life
- ~5–60 min parent peptide; analogs may be longer
- Route tags
- Route-dependent / verify
- Evidence level
- Early human/preclinical
- Clinical status
- Experimental
- Value-for-money score
- 5 / 10
Reported protocol signal
Treatment length: 4-6 weeks SQ: • 5 mg three times a week for 4-6 weeks, followed by 5 mg once a week for 4 weeks. Can repeat this cycle 3-4 times a year (Dr. Seeds) • 5 mg three times a week for 4-6 weeks (Metabolic Optimization Guide) • 10 mg once a week up to 10 weeks in a row every year (Tailor Made Compounding Catalog, Ben Greenfield’s “Boundless”) • 10 mg once a week for 4 weeks, followed by another cycle within 12-months (Dr. Rob Kominisrek) • See SS-31 for another protocol
For orientation only. See disclaimer — always consult a licensed clinician before use.
Notes
May promote functional adaptation