SS-31 / Elamipretide

Mitochondrial / Longevity

Mitochondrial function support

Reading this compound Reference only

Information below is educational. Dosing, mechanisms and status fields are compiled from the source list at the bottom of this page — always verify against a licensed clinician before use.

Reference-only summary of publicly discussed or source-listed patterns. Not medical advice and not a personal recommendation.

Mechanism & Use

Compound type: Mitochondrial peptide
Primary mechanism: Cardiolipin/inner mitochondrial membrane stabilization
Primary market use: Mitochondrial disease / aging

Pharmacology

Molecular weight (Da): 639.8
Oral bioavailability: N/A
Half-life: ~4 h
Route tags: Route-dependent / verify
Evidence level: Clinical
Clinical status: Investigational
Value-for-money score: 5 / 10

Reported protocol signal

SQ: • 4 mg daily for 10-20 days • 2 mg on the first day, then 4 mg daily for 12 days (for 50 mg total) (Reddit) Protocols with MOTS-C and Humanin: • 2 months of SS-31, after one month start 2 months MOTS-C, after MOTS-C, one month Humanin. When that ends, resume MOTS-C for 2-3 months then repeat the whole cycle. The humanin can be omitted and MOTS-C continued. MOTS-C 3 months on, 1 month off. This info from a private practitioner, not published material

For orientation only. See disclaimer — always consult a licensed clinician before use.

Notes

Durable only if downstream tissue function improves

Sources

https://clinicaltrials.gov/